AULTON.S PHARMACEUTICS. THE DESIGN AND MANUFACTURE OF MEDICINES

DESCRIPTION

From a reviewof the previousedition:

'For allthe pharmacy students out there part of yourpharmacy degree will be to studyformulation design and pharmaceutics. This is theholy grail of pharmaceutical technology books. The text readswell and introduces difficult concepts in a more easy-to-understandway, it isdefinitely worth the money tohelp you get through themodule, if you're doing a research project in pharmaceutical design then thiswould also be an excellent buy.Thisis essential for passing examsand developing professional competence.'

This is the best known text on pharmaceutics.Its strength lies mainly in being a complete course in one book. Reviewersconsistently praise its comprehensiveness and its extremelyhigh quality-quality content. Pharmaceutics is one of themost diverse subject areas in pharmaceutical science and an understandingof it isvital for all pharmacists and scientists involved in converting drugs to medicines that can be safely delivered to a patient. Theeditorial and author team deliver a tour de force of accessibility,coverage and currency in this new edition ofa world-class textbook.

Key Features:

Relevant chemistrycovered throughout

Reflects currentand future use of biotechnology products throughout

Covers ongoing changesin our understanding of biopharmaceutics, certain areas ofdrug delivery and the significance of the solidstate

Includes thescience of formulation and drug delivery

Designed andwritten for newcomers to thedesign of dosage forms

Key pointsboxes throughout

Summaries at theend of eachchapter

New to this Edition

Fully updatedthroughout, with particularfocus on delivery of biopharmaceuticals,nanotechnology and nanomedicines, parenteral andocular drug delivery mechanisms.

Now comes withonline access on StudentConsult.

TABLE OF CONTENTS

What is pharmaceutics?

Design ofdosage forms

PART 1 Scientificprinciples of dosage form design

Dissolution andsolubility

Properties ofsolutions

Surfaces andinterfaces

Disperse systems

Rheology

Kinetics

PART 2 Particlescience and powder technology

Solid-stateproperties

Particle sizeanalysis

Particle sizereduction and size separation

Mixing

Powder flow

PART 3 Pharmaceuticalmicrobiology and serialization

Fundamentals of microbiology

Pharmaceutical applicationsof microbiological techniques

Action ofphysical and chemical agents on microorganisms

Principles ofsterilization

Sterilization in practice

PART 4 Biopharmaceuticalprinciples of drug delivery

Introduction tobiopharmaceutics

Gastrointestinal tract - physiology and drug absorption

Bioavailability - physicochemical and dosage form factors

Assessment ofbiopharmaceutical properties

Dosage regimens

PART 5 Dosageform design and manufacture

Pharmaceutical preformulation

Solutions

Clarification

Suspensions

Emulsions andcreams

Powders, granules and granulation

Drying

Tablets andcompaction

Modified-releaseoral drug delivery

Coating oftablets and multiparticulates

Hard capsules

Soft capsules

Dissolution testingof solid dosage forms

Parenteral drug delivery

Pulmonary drug delivery

Nasal drug delivery

Ophthalmic drug delivery

Topical andtransdermal drug delivery

Rectal and vaginal drug delivery

The formulationand manufacture of plant medicines

Delivery ofbiopharmaceuticals

Pharmaceutical nanotechnologyand nanomedicines

Design andadministration of medicinesfor children and the elderly

Part 6 Packagingand stability of pharmaceutical products

Packaging

Chemical stabilityin dosage forms

Microbial contamination,spoilage and preservation of medicines

Product stabilityand stability testing

Online self assessment